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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mater Sci Eng C Mater Biol Appl. 2020 Jul 4;117:111251. doi: 10.1016/j.msec.2020.111251

Fig. 4:

Fig. 4:

Size of drug (GemRA)-loaded PGRA micelles and the morphology determined via (A) dynamic light scattering (DLS) and transmission electron microscopy (TEM), size of the scale bar in TEM image = 50 nm; (B) stability of GemRA loaded micelles in aqueous solution (stored at 4 °C in between DLS and zeta potential measurements which were made at 25 °C (average of 5 measurements)); (C) stability of GemRA-loaded NPs in fetal bovine serum (FBS) at 37 °C (one measurement per time point); (D) drug retention characteristics of the GemRA-loaded NPs at pH 7.4, 37 °C in comparison to free gemcitabine (N=2); (E and F) comparison of the stability of free gemcitabine, GemRA and drug-loaded micelles towards cytidine deaminase deactivation to the inactive gemcitabine metabolite dFdU (2′,2′-difluorodeoxyuridine), (E) shows amount of drug left over time and (F) shows the amount of dFdU formed (N=2).