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. 2020 Nov 23;8(2):e001617. doi: 10.1136/jitc-2020-001617

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A–C) Effects of miR-34a-5p over-expression on the endogenous levels and secretion of CXCL10 and CXCL11 in M1 macrophages. Monocytes were differentiated in M1 macrophages, transfected with ANC, or miR-34a-5p mimic, and activated with IFN-γ and LPS. Subsequently, the CXCL10 and CXCL11 endogenous levels were measured by western blots (A, one representative western blot is displayed) and quantified from three independent experiments from two different donors (B) Three asterisks correspond to p value ≤0.001 and one asterisk to a p value 0.01<p≤0.05. The secretion was measured by ELISA (C). ELISA data were quantified from three independent experiments from two different donors. Three asterisks correspond to p value ≤0.001. Data are represented as mean±SEM. (D) Hypothesis of the impact of miR-34a-5p over-expression on antitumor-response.