Table 7.

Pharmacokinetic ADMET properties and oral toxicity studies of phyto-drugs.

Compound name/ Properties	Curcumin	Demethoxycur-cumin	Isoflavone	Flavonoid	Terpinen-4-ol	Nimbin	Piperine
LD50	2000 mg/kg	2000 mg/kg	500 mg/kg	5000 mg/kg	1016 mg/kg	1000 mg/kg	350 mg/kg
Human ether-a-go-go- related gene	Weak inhibitor	Weak inhibitor	Weak inhibitor	Weak inhibitor	Weak inhibitor	Weak inhibitor	Weak inhibitor
Inhibition	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor
AMES toxicity	Non AMES toxic	Non AMES toxic	AMES toxic	Non AMES toxic	Non AMES toxic	Non AMES toxic	Non AMES toxic
Carcinogens	Non-carcinogens	Non- carcinogens	Non-carcinogens	Non-carcinogens	Non-carcinogens	Non-carcinogens	Non-carcinogens
Fish toxicity	High FHMT	High FHMT	High FHMT	High FHMT	High FHMT	Low FHMT	High FHMT
TetrahymenaPyriformis toxicity	High TPT	High TPT	High TPT	High TPT	High TPT	High TPT	High TPT
Honey bee toxicity	High HBT	High HBT	High HBT	High HBT	High HBT	High HBT	High HBT
Bio-degradation	Not ready bio-degradable	Not ready bio-degradable	Ready bio-degradable	Not ready bio-degradable	Not ready bio-degradable	Not ready bio-degradable	Ready bio-degradable
Acute oral toxicity	III	III	III	III	III	III	III