Table 2.

Studies analyzing the anti-inflammatory effects of dietary polyphenols via epigenetic regulation in several chronic inflammatory conditions

Type of polyphenol	Dose/concentration	Study model	Epigenetic signatures	Modification types	Reference
Grape extract resveratrol	8 mg	PBMCs from T2DM and hypertensive patients	miR-21, miR-181b, miR-663, and miR-30c2 expressions	↑	[33]
Resveratrol	10 μM	LPS-stimulated RAW 264.7 macrophages	miR-146a expression	↓	[197]
Resveratrol	1 g/kg	SAMP8 mice offspring	Nrf2 and Nfkb methylation levels	↑	[198]
Resveratrol	10 μM	ARPE-19 cells exposed to GOx and LPS	DNMT and SIRT1 expressions	↑	[199]
Trans-resveratrol	50 mg/kg	Postnatal rats exposed to perinatal asphyxia	miR132 and miR15a expressions	↓	[200]
Mango (Mangifera indica L.) polyphenols	10 mg/L	Rats exposed to dextran sodium sulfate (DSS)	miR-126 expression	↑	[34]
Mango (Mangifera indica L.) polyphenols	10 mg/L	LPS-treated CCD-18Co cells	miR-126 expression	↑	[34]
Oleocanthal and oleacein	25 µM/L	Adipocytes	miR-155-5p, miR-34a-5p and let-7c-5p	↑	[201]
Hydroxytyrosol	10 μM/L	Adipocytes	miR-155-5p, miR-34a-5p	↓	[202]
Polyphenol-rich green tea	500 mg/body weight	White adipose tissue	miR-335	↓	[203]
Apigenin	10 mg/kg	C57BL/6 J mice	let-7f	↑	[204]
(–)-Epicatechin	5 μM	THP-1 cells exposed to high glucose	H3K9 acetylation and H3K4 dimethylation	↓	[35]
Polyphenol-rich lingonberries (Vaccinium vitis-idaea)	20% w/w	High-fat fed C57BL/6 J mouse	Ncor2 methylation	↑	[205]
Luteolin	10 μM	THP-1 cells exposed to high glucose	HAT activity	↓	[206]
Gallic acid	25 μM	THP-1 cells exposed to high glucose	HAT activity HDAC2 expression	↓	[207]
Fisetin	10 μM	THP-1 cells exposed to high glucose	HAT activity	↓	[208]
Red raspberry polyphenols	10 µg/ml−1	J774 macrophages	H3K27Ac expression	↓	[209]
Epigallocatechin gallate	20 μM	Regulatory T cells	HDAC activity	↑	[210]