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. 2020 Nov 23;17:186. doi: 10.1186/s12985-020-01456-1

Table 2.

Non-synonymous differences in the amino acid sequences in the coding regions between Kgs-c1 and other MDV strains

Gene name Product Position JPN USA CHN EU
Kgs-c1 RB-1B 648a Md5 GA CU-2 GX 0101 LMS 814 ATE
2539		 C12: 130 MD70/13 CVI988
MDV004 23 kDa nuclear protein 76 S R S S R R S S R R R R R
MDV005 R-LORF7 (Meq) 77 E K K K K E E E E E E K E
80 Y D D D D D Y Y D Y Y D D
115 A V V V V V A A A V V V V
176/235* S P A P P P R R P P P P P
217/ 276* A P A A P P A A P P P P P
MDV006.6 B68 (VZV transducing protein) 14 I T T T T T T T T T T T T
MDV010 v-lipase 352 A V V V V V V V V A V V V
MDV015 UL3 (nuclear phosphoprotein) 6 C G G G G G G G G G G P G
MDV016 UL4 (nuclear protein) 244 I V V V V V V V V V V V V
MDV018 UL6 (DNA packaging, minor capsid protein) 243 D N N N A N N N N N N N N
MDV019 UL7 (DNA packaging/cleavage, capsid protein) 172 K Q Q Q Q Q Q Q Q Q Q Q Q
MDV020 UL8 (DNAhelicase-primase associated protein) 84 D E D D D D D D D D D D D
MDV020.5 UL8.5 (origin binding protein) 42 R G G G G G R R G G R G G
462 A V V V V V V V V V V V V
MDV021 UL9 (origin binding protein) 395 R G G G G G R R G G R G G
815 A V V V V V V V V V V V V
MDV040 UL27 (glycoprotein B) 537 F S S S S S S S S S S S S
MDV042 UL29 (single-strand DNA binding protein) 918 A V V V A A A A A A A V A
1,183 A V V V A A A A A A A V A
MDV043 UL30 (DNA polymerase) 1,087 D N N N N N N N D N N N N
1,095 A V V V V V V V A V V V V
MDV044 UL31 (nuclear phosphoprotein) 39 R G G G G G R R R G R G G
MDV046 UL32 (DNA packaging) 415 T I I I I I T T T T T I I
MDV047 UL34 (membrane phosphoprotein) 228 A G G G G G G G G G G L G
MDV049** UL36 (large tegument protein) 3,241 E K E E E E E E E E E E E
MDV050 UL37 (tegument protein) 3 A V V A A A A A A A A V A
258 R Q Q Q Q Q R R R R R Q Q
521 H R R R R R H H H H H R R
MDV051 UL38 (capsid protein) 68 A T T T T T A A A A A T A
MDV055 UL42 (DNA polymerase) 114 I V V V V V I I I I I V V
166 V A A A A A A A A V A A A
MDV056 UL43 (probable membrane protein) 305 E K K K E K E E E T E K E
399 I V I V V V V V V V V V V
MDV071 LORF10 (VZV ORF2) 34 L W W W L L L L L W L W L
MDV073 R-LORF14a (pp38) 109 G E E E E G G G G G G G G
115 L P P P P P P P P P P P P
MDV084 ICP4 181 S P S P P P P P P P P P P
532 R C C C R C R R R R R C C
1,084 L P P P L L L L L L S P L
1,993 P L L L L L P P P P P L L
2,017 E K K K K K E E E E E K K
2,111 R L L L R P R R R R R L L
MDV091 US2 (transmission associated protein) 51 A V V V A V A V A A A V A
MDV092 US3 (serine/threonine protein kinase) 4 T S S S T S T S T S T S T
109 P S S S P P P P P P P S P
MDV095 US7 (glycoprotein I) 3 V L L L V L V L V L Y L L
112 G H H H G H G H G D G D H
142 S A A A S A S A S A S A A
155 V A A A V A V A V A V A A
223 V I I I V I V I V I V I I
MDV096 US8 (glycoprotein E) 67 I V V V V V V V V V V V V
370 I V V V V V V V I I V V V
392 L I I I I I L I L L L I I
455 A D D D D D A D A A A T D
469 D A A A A A D A D D D A A

Italics indicated that the sequences are indentical to those of Kgs-c1

Differences in the coding regions whose functions, including the prediction, were indicated. The differences in the coding regions in Internal Repeat Long (IRL) and Terminal Repeat Short (TRS) between Kgs-c1 and RB-1B were omitted, because the same differences were contained in the same regions in Terminal Repeat Long (TRL) and Internal Repeat Short (IRS), respectively

*The meq genes in CU-2, 814 and CVI988 contain the insertion in the proline-rich repeat (PRR) sequences in the transactivation domain, and therefore, the number of PRRs are increased. The amino acid residues at positions 176 and 235 or 217 and 276 were located at PRR, and those sequences are the same

**Differences in MDV049 (UL36 (large tegument protein)) were indicated except for variable regions at the C-terminus