. Author manuscript; available in PMC: 2020 Nov 24.

Published in final edited form as: J Huntingtons Dis. 2019;8(4):467–482. doi: 10.3233/JHD-190364

Table 3.

Pearson correlations to support convergent and discriminant validity of the new Neuro-QoL/PROMIS mental health PROs

	Emotional and Behavioral BDyscontrol CAT	Positive Affect and Well-Being CAT	Stigma CAT	Anger CAT	Anxiety CAT	Depression CAT
Generic HRQOL Measures
-
EQ5D Index Score^*	−0.338^**	0.389^**	−0.499^**	−0.334^**	−0.371^**	−0.416^**
EQ5D Health Scale^*	−0.301^**	0.408^**	−0.453^**	−0.313^**	−0.312^**	−0.404^**
Rand 12 Physical Health Scale^*	−0.305^**	0.356^**	−0.543^**	−0.299^**	−0.286^**	−0.338^**
Rand 12 Mental Health Scale^*	−0.602^**	0.574^**	−0.499^**	−0.668^**	−0.709^**	−0.709^**
WHODAS	0.441^**	−0.428^**	0.658^**	0.436^**	0.414^**	0.500^**
Patient Health Questionnaire 9 (PHQ9)	0.590^**	−0.552^**	0.685^**	0.640^**	0.641^**	0.704^**
General Anxiety Disorder 7-item (GAD7)	0.659^**	−0.516^**	0.608^**	0.674^**	0.703^**	0.639^**
Clinician-Rated Functioning
-
UHDRS Motor	0.034	−0.079	0.070	0.027	0.024	0.075
UHDRS Functional Assessment	−0.113	0.158^**	−0.375^**	−0.060	−0.096	−0.160^*
UHDRS Total Functional Capacity	−0.143^*	0.183^**	−0.417^**	−0.088	−0.073	−0.157^*
Clinician-Rated Behavioral Status
-
PBAs Aggressive Behavior	−0.377^**	0.240^**	−0.286^**	−0.395^**	−0.287^**	−0.287^**
PBAs Anxiety	−0.447^**	0.368^**	−0.414^**	−0.482^**	−0.554^**	−0.450^**
PBAs Apathy	−0.395^**	0.326^**	−0.389^**	−0.360^**	−0.360^**	−0.413^**
PBAs Depressed Mood	−0.479^**	0.435^**	−0.457^**	−0.551^**	−0.516^**	−0.634^**
PBAs Disoriented Behavior	−0.219^**	0.232^**	−0.293^**	−0.196^*	−0.160^*	−0.250^**
PBAs Irritability	−0.503^**	0.289^**	−0.415^**	−0.553^**	−0.428^**	−0.407^**
PBAs Obsessive Compulsive Behavior	−0.169^**	0.127^*	−0.210^**	−0.256^**	−0.214^**	−0.182^*
PBAs Perseverative Thinking	−0.285^**	0.156^*	−0.340^**	−0.336^**	−0.194^*	−0.229^**
PBAs Suicide	−0.354^**	0.345^**	−0.301^**	−0.436^**	−0.401^**	−0.522^**

Note. PROs = patient-reported outcomes; HRQOL = health-related quality of life; CAT = computer adaptive test; SF = short form; UHDRS = Unified Huntington’s Disease Rating Scales; PBAs = Problem Behaviors Assessment.

^**

Correlation is significant at the 0.01 level (2-tailed).

Correlation is significant at the 0.05 level (2-tailed).