Table 2.
Clinical characteristics of gastric adenocarcinoma by EBV status
| EBV-positive (n=22) | EBV-negative (n=1013) | aOR (95% CI) | |
|---|---|---|---|
| Patient Characteristics | |||
| Male | 19 (86.4)b | 809 (79.9) | 1.60 (0.47-5.45) |
| cAge (IQR) | 51 (44-62) | 60 (53-65) | p = 0.01 |
| Lifestyle Factors | |||
| Ever alcohol | 13 (59.1) | 581 (57.4) | 0.79 (0.30-2.10) |
| Ever tobacco | 17 (77.3) | 714 (70.5) | 1.18 (0.32-4.31) |
| Ever pickled vegetable consumption | 19 (86.4) | 875 (86.4) | 0.98 (0.28-3.36) |
| Ever pickled vegetable juice consumption | 14 (63.6) | 573 (56.6) | 1.43 (0.59-3.45) |
| Family History | |||
| Any Cancer | 4 (18.2) | 348 (34.4) | 0.40 (0.13-1.18) |
| Upper GI Cancer | 2 (9.1) | 217 (21.4) | 0.35 (0.08-1.52) |
| Esophageal Cancer | 2 (9.1) | 129 (12.7) | 0.70 (0.16-3.02) |
| Gastric Cardia Cancer | 0 (0) | 37 (3.7) | N/A |
| Gastric Non-cardia Cancer | 0 (0) | 79 (7.8) | N/A |
| Tumor Characteristics | |||
| Anatomic Subsite | |||
| Cardia | 6 (27.3) | 655 (64.7) | 0.22 (0.08-0.59) |
| Differentiation | |||
| Well | 2 (9.1) | 362 (35.7) | 1.00 |
| Moderate | 6 (27.3) | 148 (14.6) | 6.63 (1.31-33.45) |
| Poor | 14 (63.6) | 440 (43.4) | 5.61 (1.26-24.98) |
| Missing | 0 | 63 (6.2) | |
| Lauren Classification | |||
| Intestinal-type | 8 (36.4) | 514 (50.7) | 1.00 |
| Diffuse-type | 14 (63.6) | 436 (43.0) | 2.06 (0.85-5.01) |
| Missing | 0 (0) | 63 (6.2) | |
| Primary Tumor Stage | |||
| Early (T0, Tis, T1, T2) | 4 (18.2) | 75 (7.4) | 1.00 |
| Late (T3, T4) | 18 (81.8) | 935 (92.3) | 0.39 (0.13-1.19) |
| Missing | 0 (0) | 3 (0.3) | |
| Regional Lymph Node Status | |||
| Negative | 6 (27.3) | 143 (14.1) | 1.00 |
| Positive | 12 (54.6) | 755 (74.5) | 0.39 (0.14-1.07) |
| Missing | 4 (18.2) | 115 (11.4) | |
| Distant Metastasis | |||
| Negative | 10 (45.5) | 255 (25.2) | 1.00 |
| Positive | 12 (54.6) | 753 (74.3) | 0.42 (0.18-0.99) |
| Missing | 0 (0) | 5 (0.5) | |
| Chemotherapy | |||
| Yes | 2 (9.1) | 76 (7.5) | 1.00 |
| No | 18 (81.8) | 866 (85.5) | 1.22 (0.28-5.38) |
| Missing | 2 (9.1) | 71 (7.0) | |
| Radiotherapy | |||
| Yes | 11 (50.0) | 461 (45.5) | 1.00 |
| No | 9 (40.9) | 481 (47.5) | 1.34 (0.55-3.29) |
| Missing | 2 (9.1) | 71 (7.0) | |
a
Age- and sex-adjusted odds ratios (ORs) with 95% confidence intervals for comparison between gastric adenocarcinoma originating from cardia and non-cardia (reference) anatomic subsites, when applicable. Unadjusted odds ratio shown for sex, and p-value shown for age.
b
Number of patients (column percent)
c
Median age (interquartile range) noted in years