Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 10;12:556008. doi: 10.3389/fnagi.2020.556008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Lin, Li, Cheng, Zhao and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Chronic Mn treatment increased β-amyloid (Aβ) production in 3×Tg-AD mouse brains. (A) APP mRNA level in 3×Tg-AD mouse brains, determined by semiquantitative RT-PCR with GAPDH mRNA serving as the internal control, was increased in the cerebral cortex and hippocampus of Mn-treated 3×Tg-AD mice. (B–D) The protein expression of APP and Aβ in 3×Tg-AD mouse brain, determined by Western blot, was increased in the cortex and hippocampus of Mn-treated 3×Tg-Ad mice. β-actin was used as the internal control. n = 5 mice for each group. *p < 0.05, compared with the control group, t-test.