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. 2020 Nov 10;12:556008. doi: 10.3389/fnagi.2020.556008

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Copyright © 2020 Lin, Li, Cheng, Zhao and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mn-exposure did not influence amyloidogenic processing of APP in N2a cells transfected with APPsw. (A–D) Western blot analysis was carried out to examine the expression levels of APP cleavage enzymes, BACE1, ADAM10, and PS1, in APPsw-N2a cells. β-actin was used as an internal control. No significant change was detected in the protein levels of BACE1, ADAM10, and PS1 in 100 or 500 μM Mn-treated APPsw-N2a cells. (E–H) Western blot analysis was used to determine the protein levels of C99 and C83 in 100 or 500 μM Mn-treated APPsw-N2a cells. There were no significant changes in the C99 and C83 level in Mn-treatment cells compared with the controls. n = 5 mice for each group, p > 0.05, one-way ANOVA.