Figure 4.

Effect of CAPE on cognitive and physiological functions in the Drosophila model of Alzheimer’s disease (AD). (A) Schematic model showing UAS-Tau R406W strain (model for AD) and ELAV-GAL4 strain at parental stage (P) and their progeny UAS-GAL4 (at F₁), along with wild-type (WT) strains (top panel), and scheme of media/culture, CAPE treatment, and diverse investigated properties of flies obtained from all four groups (bottom panel). (B) Quantitation of fly counts reflecting the viability of male and female flies in wild and Alzheimer’s strains in control and CAPE-treated groups. (C) Quantitation showing negative geotaxic movement is increased by the treatment of CAPE in male Alzheimer’s strains. (D) Quantitation showing the number of eggs laid by both WT and Alzheimer’s flies were significantly increased in response to the treatment with CAPE. (E) Quantitation of percentage survival rate showing increased stress response/thermal tolerance in both male WT and Alzheimer’s flies in CAPE-treated groups. The data were expressed as mean ± SD. The p-values were represented as *p < 0.05, **p < 0.01, and ***p < 0.001. NS, non-significant.