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. 2020 Nov 6;10:514943. doi: 10.3389/fcimb.2020.514943

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Copyright © 2020 Zuo, Fu, Zhao, Du, Hu, Zhao, Ji, Feng, Zhumajiang, Zhou, Tian, Pei, Yu and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional alterations of the salivary microbiome between men with head and neck cancer (HNC_M, n = 56) and healthy controls (HC_M, n = 64) using PICRUSt2. (A) Environmental Information Processing, (B) Genetic Information Processing, (C) Human Diseases, (D) Organismal Systems, (E) Cellular Processes, (F) Metabolism, (G) Human Diseases_Immune diseases, (H) Human Diseases_Cancers: Overview, (I) Human Diseases_Cancers: Specific types, (J) Metabolism_Glycan biosynthesis and metabolism, (K) Metabolism_Lipid metabolism, (L) Metabolism_Biosynthesis of other secondary metabolites, (M) Human Diseases_Immune diseases_Primary immunodeficiency, (N) Human Diseases_Cancers: Overview_Pathways in cancer, (O) Human Diseases_Cancers: Overview_Viral carcinogenesis, (P) Human Diseases_Cancers: Overview_Chemical carcinogenesis, (Q) Human Diseases_Cancers: Overview_Proteoglycans in cancer, (R) Human Diseases_Cancers: Overview_Central carbon metabolism in cancer, (S) Human Diseases_Cancers: Overview_Choline metabolism in cancer, (T) Human Diseases_Cancers: Specific types_Renal cell carcinoma, (U) Metabolism_Glycan biosynthesis and metabolism_Lipopolysaccharide biosynthesis, (V) Metabolism_Lipid metabolism_Steroid hormone biosynthesis, (W) Metabolism_Biosynthesis of other secondary metabolites_Neomycin, kanamycin and gentamicin biosynthesis, (X) Metabolism_Metabolism of terpenoids and polyketides_Sesquiterpenoid and triterpenoid biosynthesis. Violin plots showing the most predominant functional alterations in the HNC group. PICRUSt2: Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2.