Table 3.

Metabolites that showed significantly altered levels between SW480 colorectal cancer cells expressing truncated APC and those expressing full‐length APC

	Chemical class	Fold induction	P‐value
		Truncated/full‐length APC	Truncated versus full‐length APC
1,5‐Anhydro‐d‐glucitol	Carbohydrates	3.1500	0.03200*
1,6‐Anhydroglucose	Carbohydrates	1.7500	0.02900*
2‐Aminopimelic acid	Dicarboxylic acids	3.0100	0.00088*
2‐Hydroxypyridine	Hydroxy acids	1.4900	0.03000*
6‐Hydroxynicotinic acid	Aromatic acids	0.3900	0.02500*
Acetoacetic acid	Keto‐acids	6.3100	0.00005*
Alanine	Amino acids	1.4800	0.00100*
Arabitol	Alcohols and polyols	0.5200	0.04100*
Asparagine	Amino acids	3.7400	0.00200*
Aspartic acid	Amino acids	1.8700	0.01200*
Citric acid + isocitric acid	Tricarboxylic acids	2.7600	0.00077*
Creatinine	Amino ketones	2.2500	0.00120*
Cystathionine	Amino acids	3.9600	0.00046*
Fumaric acid	Dicarboxylic acids	2.1000	0.00920*
Glycolic acid	Hydroxy acids	1.6300	0.00089*
Gulcono‐1,4‐lactone	Carbohydrates	2.1800	0.00009*
Inositol	Alcohols and polyols	0.4600	0.00002*
Kojic acid	Hydroxy acids	2.4900	0.01500*
Malic acid	Dicarboxylic acids	5.3300	<0.00001*
Meso‐erythritol	Alcohols and polyols	0.7200	0.00200*
Nicotinamide	Cyclic amines	0.7400	0.01000*
Nicotinic acid	Amino acids	0.0017	<0.00001*
N‐methylethanolamine	Amino alcohols	1.3000	0.03500*
Proline	Amino acids	0.4800	0.00006*
Putrescine	Polyamines	1.7200	0.00087*
Pyroglutamic acid	Amino acids	2.9600	0.00021*
Pyruvate + oxalacetic acid	Keto‐acids	1.8400	0.04700*
Ribitol	Alcohols and polyols	0.2400	0.00001*
Succinic acid (or aldehyde)	Dicarboxylic acids	18.4600	0.00008*
Tagatose	Carbohydrates	1.6900	0.00530*
Thymine	Pyrimidines and derivatives	2.5800	0.00020*

Values are represented as the fold‐induction of the peak intensity for SW480 cells expressing truncated APC (n = 5) against that for SW480 transfectants expressing full‐length APC (n = 5). All data are represented in Table S3, and the metabolites that showed significantly altered levels are shown in Table 3. P‐values were calculated using Student's t‐test; *P < 0.05.