Table 4.

Metabolites that showed significantly altered serum levels in HT‐29 cell‐implanted nude mice

	Chemical class	Fold induction	P‐value
		HT‐29‐implanted mice/control	HT‐29‐implanted mice versus control
2‐Aminoethanol	Amino alcohols	0.77	0.00026*
Acetoacetic acid	Keto‐acids	0.54	0.00066*
Acetylsalicylic acid	Salicylates	1.84	0.02800*
Aspartic acid	Amino acids	1.39	0.03000*
β‐Alanine	Amino acids	0.68	0.00930*
Citric acid + isocitric acid	Tricarboxylic acids	0.73	0.00260*
Citrulline	Amino acids	1.59	0.00140*
Fumaric acid	Dicarboxylic acids	0.47	0.00015*
Glucose	Carbohydrates	0.88	0.04200*
Glyceric acid	Hydroxy acids	0.78	0.00410*
Glycerol	Alcohols and polyols	0.75	0.00001*
Hippurate	Amino alcohols	1.68	0.02000*
Histidine	Amino acids	1.45	0.00710*
Homocysteine	Amino acids	0.64	0.03100*
Hydrocinnamate	Aromatic acids	1.94	0.01800*
Hypoxanthine	Purines and purine derivatives	0.38	0.02500*
Isoleucine	Amino acids	1.48	0.00014*
Lactic acid	Hydroxy acids	0.84	0.00530*
Lysine	Amino acids	1.20	0.02100*
Malic acid	Dicarboxylic acids	0.44	0.00009*
Ornithine	Amino acids	2.00	0.00029*
Phenylalanine	Amino acids	1.52	0.00031*
Proline	Amino acids	1.62	0.00780*
Pyruvate + Oxalacetic acid	Keto‐acids	0.58	0.00021*
Ribose	Carbohydrates	0.63	0.00007*
Ribulose	Carbohydrates	0.55	0.00023*
Serine	Amino acids	1.37	0.03100*
Succinic acid(or aldehyde)	Dicarboxylic acids	0.62	0.00310*
Tagatose (or psicose)	Carbohydrates	2.11	0.00090*
Threonine	Amino acids	1.76	0.00210*
Trans‐4‐hydroxy‐L‐proline	Amino acids	1.59	0.02400*
Urea	Amino ketones	0.88	0.04200*
Valine	Amino acids	1.40	0.00053*

Values are represented as the fold‐induction of the peak intensity for HT‐29 cell‐implanted nude mice (n = 9) against that of the corresponding controls (n = 12). All data are represented in Table S4, and the metabolites that showed significantly altered levels are shown in Table 4. P‐values were calculated using Student's t‐test; *P < 0.05.