Table 5.

Metabolites detected in the serum of SW480 cells with truncated APC and SW480 transfectants with full‐length APC implanted in nude mice

	Chemical class	Fold induction (SW480 cell‐implanted nude mice)			P‐value
		Mutation/full‐length	Full‐length/control	Mutation/control	Mutation versus full	Full versus control	Mutation versus control
2‐Hydroxypyridine	Hydroxy acids	0.35	1.77	0.62	0.0190*	0.04600*	0.0540
Alanine	Amino acids	1.02	0.72	0.74	0.8500	0.00800*	0.0440*
Arabitol	Amino acids	0.55	3.67	2.01	0.0440*	0.00046*	0.0100*
α‐Sorbopyranose (or fructose)	Carbohydrates	0.49	1.08	0.52	0.0350*	0.56000	0.0210*
Asparagine	Amino acids	0.81	0.82	0.67	0.2200	0.13000	0.0260*
Coniferyl alcohol	Alcohols and polyols	1.25	0.67	0.84	0.0170*	0.00180*	0.0880
Glucose	Carbohydrates	1.23	0.87	1.08	0.0052*	0.07700	0.2400
Histidine	Amino acids	0.90	0.77	0.69	0.3600	0.00510*	0.0046*
Ketoisoleucine	Keto‐acids	1.18	0.63	0.75	0.3300	0.00300*	0.0390*
Lactic acid	Hydroxy acids	1.01	0.70	0.70	0.9100	0.00290*	0.0110*
Lauric acid	Fatty acids	1.02	1.09	1.11	0.5900	0.02900*	0.0021*
Lysine	Amino acids	0.89	0.82	0.73	0.2700	0.03400	0.0032*
Malic acid	Dicarboxylic acids	0.75	0.89	0.66	0.2600	0.49000	0.0690
n‐Caprylic acid	Fatty acids	0.42	1.82	0.77	0.0140*	0.06600	0.6700
Pyruvate + Oxalacetic acid	Keto‐acids	0.89	0.76	0.68	0.4100	0.08000	0.0480*
Rhamnose	Carbohydrates	2.07	0.57	1.18	0.0340*	0.16000	0.6100
Ribitol	Alcohols and polyols	0.27	1.70	0.46	0.0180*	0.12000	0.0970
Ribose	Carbohydrates	0.66	1.34	0.88	0.0019*	0.03500*	0.4800
Succinic acid (or aldehyde)	Dicarboxylic acids	0.87	0.83	0.72	0.3700	0.21000	0.0480*
Tagatose	Carbohydrates	1.15	0.75	0.86	0.0380*	0.34000	0.6300
Taurine	Amino acids	0.65	1.86	1.21	0.0420*	0.02500*	0.5700
Uracil	Pyrimidines and derivatives	1.11	0.69	0.76	0.0640	0.00310*	0.0220*
Xylose	Carbohydrates	0.99	0.43	0.43	0.9700	0.02100*	0.0360*

Values are represented as the fold‐induction of the peak intensity among nude mice implanted with SW480 cells with truncated APC (n = 4), SW480 transfectants full‐length APC (n = 5), and the corresponding control nude mice (n = 6). All data are represented in Table S5, and the metabolites that showed significantly altered levels are shown in Table 5. P‐values were calculated using Student's t‐test; *P < 0.05.