. 2020 Jun 15;36(8):e3335. doi: 10.1002/dmrr.3335

TABLE 2.

Cardiorespiratory fitness and cardiac function

Cardiorespiratory fitness variables	Sitagliptin n = 19			Canaglifozin n = 17			P value (time_X_group interaction)
Cardiorespiratory fitness variables	Baseline	12 wk	P value	Baseline	12 wk	P value	P value (time_X_group interaction)
Peak VO₂, mL min⁻¹	1769 ± 489	1710 ± 392	0.21	1583 ± 409	1600 ± 454	0.86	0.15
VE/VCO₂ slope	32.6 ± 7.2	32.5 ± 5.8	0.65	34 ± 6.1	33.8 ± 4.2	0.66	0.98
Peak VO₂, mL Kg⁻¹ min⁻¹	15.3 ± 3.5	14.8 ± 3.9	0.16	16.2 ± 3.4	16.9 ± 4.0	0.23	0.08
Peak VO₂, mL Kg_LM ⁻¹ min⁻¹	22.9 ± 5.0	22.0 ± 5.4	0.16	25.2 ± 5.0	26.7 ± 5.3	0.16	0.036
Peak VO₂ pulse, mL min⁻¹	13.9 ± 3.5	13.6 ± 3.6	0.78	12.7 ± 3.1	12.9 ± 3.5	0.53	0.46
VAT, mL Kg⁻¹ min⁻¹	11.6 ± 3.0	11.8 ± 2.9	0.93	11.7 ± 2.2	13.1 ± 2.3	0.004	0.01
OUES	2.11 ± 0.58	2.06 ± 0.55	0.64	1.72 ± 0.36	1.80 ± 0.43	0.09	0.15
RER‐matched VO₂, mL Kg⁻¹ min⁻¹	14.4 ± 3.9	14.7 ± 3.9	0.26	14.2 ± 4.2	16.9 ± 3.9	0.001	0.002
Respiratory exchange ratio	1.04 ± 0.04	1.03 ± 0.07	0.38	1.12 ± 0.11	1.0 ± 0.07	<0.001	0.001
Exercise time, s	551 ± 108	534 ± 120	0.12	561 ± 143	573 ± 151	0.69	0.13
Resting heart rate, bpm	71 ± 10	73 ± 10	0.89	70 ± 10	69 ± 11	0.23	0.43
Peak heart rate, bpm	129 ± 23	126 ± 24	0.18	125 ± 17	125 ± 15	0.82	0.46
Resting systolic blood pressure, mmHg	130 ± 20	124 ± 15	0.27	131. ±17	130 ± 17	0.91	0.37
Peak systolic blood pressure, mmHg	159 ± 29	162 ± 26	0.42	174 ± 31	174 ± 30	0.26	0.19
Resting diastolic blood pressure, mmHg	71 ± 16	69 ± 13	0.39	72 ± 13	74 ± 14	0.78	0.99
Peak diastolic blood pressure, mmHg	72 ± 13	74 ± 13	0.41	77 ± 14	76 ± 16	0.85	0.25

Echocardiographic Variables	Sitagliptin n = 19			Canaglifozin n = 17			P value (time_X_group interaction)
Echocardiographic Variables	Baseline	12 wk	P value	Baseline	12 wk	P value	P value (time_X_group interaction)
Deceleration time velocity, ms	179 (153–211)	187 (159–216)	0.13	205 (159–263)	193 (152–233)	0.08	0.02
E/E′	13.9 ± 4.6	13.4 ± 4.6	0.45	18.5 ± 13.2	16.7 ± 9.4	0.43	0.63
E/DT	0.03 ± 0.01	0.04 ± 0.02	0.82	0.03 ± 0.01	0.03 ± 0.01	0.06	0.46
LVESV index	61 (43–76)	51 (44‐61)	0.01	36 (27‐57)	37 (23‐47)	0.02	0.92
LVEDV index	78 (65–108)	81 (58‐89)	0.27	58 (42–83)	54 (42‐73)	0.86	0.68
LVEF, %	27.0 ± 6.8	30.3 ± 10.4	0.18	31.6 ± 7.5	38.8 ± 10.9	0.006	0.21
TAPSE, cm	2.18 ± 0.47	2.04 ± 0.46	0.34	2.15 ± 0.42	2.19 ± 0.54	0.29	0.16

Abbreviations: DT, deceleration time; LVEDV, left ventricular end‐diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end‐systolic volume; OUES, oxygen uptake efficiency slope; RER, respiratory exchange ratio; TAPSE, tricuspid annular plane systolic excursion; VAT, ventilatory anaerobic threshold; VE/VCO₂, minute ventilation/carbon dioxide production; VO₂, oxygen consumption.