TABLE 1.
Biological functions of DEGs potentially playing key roles in T. annulata‐mediated leukocyte transformation and dissemination
| Gene symbol | Log2 FC (TBL20) | Adj. p‐value | Log2 FC (TBL3) | Adj. p‐value | Log2 FC (ATT) | Adj. p‐value | Biological functions | References |
|---|---|---|---|---|---|---|---|---|
| MMP9 | 8.87 | 0 | 8.29 | 0 | −2.13 | 5.14 E‐94 | Metastasis formation, cancer cells invasion | PMID: 10652271 |
| SEPP1 | −3.95 | 8.74 E‐174 | −1.54 | 3.75 E‐248 | 2.63 | 1.01 E‐140 | Transports selenoprotein, tumour suppressor | PMID: 26053663 PMID: 27314080 PMID: 8884283 |
| GZMA | −2.87 | 1.45 E‐05 | −2.25 | 1.97 E‐41 | 1.02 | 9.14 E‐21 | Plays a role in killing pathogen‐infected cells and cancer cells | PMID: 18304003 PMID: 15780992 |
| RASGRP1 | −3.55 | 0 | −1.78 | 1.97 E‐41 | 1.2 | 2.15 E‐15 | Required for correct functioning of lymphocytes in chronic infections | PMID: 17675473 |
Abbreviations: DEG, differentially expressed gene; FC, fold change.