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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Neurobiol Dis. 2020 Apr 25;141:104878. doi: 10.1016/j.nbd.2020.104878

Figure 5. gp120 ADA reduces KCC2 immunoreactivity.

Figure 5.

(A, B) Bar graphs quantifying percentage of cells immunoreactive to KCC2. Both 6 h (A) and 24 h (B) exposures to 500 pM - 1 nM gp120 ADA significantly reduced the percentage of KCC2 immunoreactive cells compared to their respective controls (†p < 0.01; n = 6), while gp120 IIIB or gp120 MN had no significant effect on KCC2 expression. Interestingly, CLP257 co-exposure failed to maintain KCC2 immunoreactivity in gp120 ADA exposed groups, but MVC showed significant rescue (*p < 0.05; n = 5 - 6), suggesting that CCR5 activation is responsible for gp120 loss.