. Author manuscript; available in PMC: 2020 Nov 24.

Published in final edited form as: Curr Opin Virol. 2020 Oct 23;43:79–87. doi: 10.1016/j.coviro.2020.09.005

Table 7:

Cumulative serologic response following a single dose of TV003 or TV005 in flavivirus-naïve subjects

	% seroconverted
	DENV-1	DENV-2	DENV-3	DENV-4
TV003 (N=58¹)	97.0	64.0	98.0	100.0
TV005 (n=59¹)	91.5	86.4	94.9	96.6
	Geometric Mean Peak Titer (Median)^2,3
	DENV-1	DENV-2	DENV-3	DENV-4
TV003 (N=82¹)	70.6 (75)	45.2 (50)	68.1 (57)	123.3 (133)
TV005 (n=59¹)	54.4 (43)	89.3 (101)	80.6 (78)	164.7 (172)
	Percent of TV005 recipients with indicated multivalent response (cumulative)
	TETRA	TRI	BI	MONO
TV003 (N=82¹)	65.5	29.3 (94.8)	5.2 (100)	0 (100)
TV005 (n=59¹)	79.7	15.3 (95.0)	1.7 (96.7)	3.3 (100)

^1.

From CIR268 and CIR279

^2.

Based on PRNT₅₀. Seropositive response is defined as a PRNT₅₀ ≥ 1:10 by Study Day 90.

^3.

PRNT₅₀ titer calculated only for those subjects who seroconverted