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. 2020 Nov 20;13:11975–11990. doi: 10.2147/OTT.S279798

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© 2020 Liu et al.

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Long intergenic non-coding RNA 519 (LINC00519) promotes tongue squamous cell carcinoma (TSCC) cell proliferation, migration and invasion and inhibits cell apoptosis. (A) SCC-15 and CAL-27 cells were transfected with small interfering RNA specific for LINC00519 (si-LINC00519) or LINC00519 overexpression plasmid pcDNA3.1-LINC00519 (pc-LINC00519), and LINC00519 expression was detected by qRT-PCR. (B) Cell counting kit-8 assay was performed to detect the proliferation of SCC-15 and CAL-27 cells upon LINC00519 depletion or upregulation. (C) Flow cytometry analysis was performed to evaluate apoptosis of in SCC-15 and CAL-27 cells transfected with si-LINC00519 or pc-LINC00519. (D and E) The migratory and invasive capacities of SCC-15 and CAL-27 cells were assessed using cell migration and invasion assays after treatment with si-LINC00519 or pc-LINC00519, respectively.

Note: *P < 0.05 and **P < 0.01.