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. 2020 Nov 20;13:11975–11990. doi: 10.2147/OTT.S279798

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© 2020 Liu et al.

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Increased metastasis-associated in colon cancer-1 (MACC1) expression reverses the effect of long intergenic non-coding RNA 519 (LINC00519) knockdown on the proliferation, apoptosis, migration and invasion of SCC-15 and CAL-27 cells. (A) MACC1 protein expression was measured by Western blotting after transfection with a MACC1 overexpression plasmid (pc-MACC1) or empty vector (pcDNA3.1) into SCC-15 and CAL-27 cells. (B–E) The pc-MACC1 or pcDNA3.1 were co-transfected with siRNA specific for LINC00519 (si-LINC00519) into SCC-15 and CAL-27 cells. Cell proliferation, apoptosis, migration and invasion were determined using a cell counting kit-8 assay, flow cytometry analysis, and cell migration and invasion assays, respectively.

Note: *P < 0.05 and **P < 0.01.