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. 2020 Nov 20;13:12015–12025. doi: 10.2147/OTT.S279723

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© 2020 Niu et al.

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Up-regulated of MCM proteins were closely correlated with shorter survival time and inhibited by Huaier. (A) Relative expression levels of MCM2, MCM3, and MCM4 in 369 HCC tissues and 160 normal tissues got form GEPIA database. (B) Kaplan-Meier survival curves for HCC patients with low (n = 182) or high (n = 182) MCM expressions (MCM2, MCM3, and MCM4) which extracted from GEPIA database. (C) The correlations of MCM2, MCM3 and MCM4 proteins with clinicopathologic stages got from GEPIA database. (D) The expression levels of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 in SK-Hep1 and Bel-7404 cell lines treated with Huaier (15 mg/mL) for 24 h measured by WB assay. (E) Relative mRNA levels of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 in SK-Hep1 and Bel-7404 cell lines treated with Huaier (15 mg/mL) for 24h (Student’s t-test, n = 3).