FIG 3.
SXT treatment and recolonization of Sm-treated adult mice by V. cholerae. SPF C57BL/6 female mice (n = 5), and the cohort 1 mice inoculated with HaitiV, formalin-inactivated HaitiV, and sodium bicarbonate, were treated with sulfamethoxazole and trimethoprim (SXT) by oral gavage and in their drinking water for 3 days to enable colonization with HaitiWT, the virulent parent strain HaitiV was derived from. All mice were dosed with 109 CFU of HaitiWT on day 0, and fecal pellets were collected daily. Open symbols represent fecal pellets from which no CFU of HaitiWT could be detected. An asterisk indicates differences with a P value of <0.05 as determined by a Mann-Whitney U test. ns, not significant.