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. 2020 Nov 23;22:275. doi: 10.1186/s13075-020-02369-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — RNA sequencing of fibroblast-like synoviocytes from 3 rheumatoid arthritis patients and interleukin-6 (IL-6)-treated samples. Group 1 (control_patient 1, control_patient 2, control_patient 3), group 2 (IL-6_patient 1, IL-6_patient 2, IL-6_patient 3). a Multi-dimensional scaling (MDS) plot showing Pearson’s correlation coefficient between log2 (fragments per kilobase of exon per million fragments mapped; FPKM) of genes. b Heat map of differentially expressed genes. Gene expression expressed as FPKM. Expression normalised by z-score transformation before visualisation with heatmap. c Volcano plot of differentially expressed genes. The most upregulated genes are towards the right and the statistically significant genes are in red, the most downregulated genes are towards the left and the statistically significant genes are in blue, and the most statistically significant genes are towards the top. b, c Cutoff q-value < 0.05. d Top 20 Gene Ontology (GO) enrichment results after IL-6 treatment. Upregulated genes in 2B were subjected to GO analysis. Top 20 GO categories are shown (−log10 (P) values were calculated by Metascape software); has, Homo sapiens