Skip to main content
. 2020 Nov 23;22:275. doi: 10.1186/s13075-020-02369-8

Fig. 6.

Fig. 6

A schematic model for IL-6-stimulated Cyr61 expression and its role in FLS migration and invasion. IL-6 and soluble IL-6 receptor complex stimulate Cyr61 expression via the ERK/ EGR3 signalling pathway. Secreted Cyr61 protein activates FLSs in an autocrine or paracrine manner and the resulting increase in extracellular Cyr61 protein enhances FLS migration and invasion. IL-6, interleukin-6; FLS, fibroblast-like synoviocyte; ERK, extracellular signal-regulated kinase; EGR3, early growth response 3