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. 2020 Nov 24;21:774. doi: 10.1186/s12891-020-03805-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Graphs show longitudinal DCE-MRI parameters in the model and control groups of wistar rats. At 12 weeks,all the differences of K^trans (min^− 1),K_ep (min^− 1) and V_e values were not statistically significant between the model and control groups. Compared with control group, (a) the K^trans (min^− 1) was significantly increased at 17 weeks and 22 weeks in model group,while(b) K_ep (min^− 1) and (c) V_e were significantly increased only at 22 weeks