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miRNAsis involved in up-regulation of the bladder cancer. Majority of miRNAs involved in proliferation of bladder cancer directly target PTEN, a negative regulator of mTOR pathway. PTEN regulation via miRNAs action allows continuous transduction of Akt/mTOR signaling which causes an abnormal cellular growth and tumor formation. Red arrow in the diagram presents down-regulation while red-cross presents inhibition of signal transduction
