Table 1.
Change in Lung Function following BT
| Baseline | 6 weeks post | 6 months post | p | |
|---|---|---|---|---|
| Spirometry | ||||
| FEV1 (l) preBD | 1.34 ± 0.65 | 1.42 ± 0.76 | 1.52 ± 0.76 | 0.024 |
| FEV1 (% pred) | 45.6 ± 12.9 | 48.1 ± 14.9 | 52.3 ± 16.1 | 0.022 |
| VC (l) preBD | 2.63 ± 0.93 | 2.68 ± 0.93 | 2.82 ± 0.97 | 0.017 |
| VC (% pred) | 73.0 ± 13.5 | 76.6 ± 15.4 | 81.3 ± 18.9 | 0.029 |
| Plethysmography | ||||
| TLC (l) | 5.55 ± 1.33 | 5.66 ± 1.42 | 5.59 ± 1.32 | 0.692 |
| TLC (% pred) | 100 ± 18 | 103 ± 26 | 102 ± 22 | 0.652 |
| FRC (l) | 3.58 ± 1.07 | 3.42 ± 0.94 | 3.40 ± 1.05 | 0.218 |
| FRC % | 121 ± 38 | 116 ± 29 | 115 ± 35 | 0.200 |
| RV (l) | 2.87 ± 0.89 | 2.84 ± 1.08 | 2.71 ± 0.93 | 0.008 |
| RV (% pred) | 145 ± 41 | 145 ± 55 | 139 ± 40 | 0.010 |
| Raw (cmH2O s l−1) | 10.58 ± 6.56 | 9.09 ± 5.36 | 7.64 ± 3.74 | 0.020 |
| Raw (% pred) | 346 ± 214 | 297 ± 175 | 248 ± 121 | 0.019 |
| sRaw (cmH2O.s) | 40.8 ± 24.8 | 37.1 ± 25.9 | 30.5 ± 20.1 | 0.022 |
| Nitrogen washout | ||||
| LCI | 12.7 ± 3.3 | 12.2 ± 3.1 | 11.8 ± 2.4 | 0.049 |
| Sacin (l−1) | 0.355 ± 0.164 | 0.327 ± 0.179 | 0.299 ± 0.165 | 0.380 |
| Scond (l−1) | 0.063 ± 0.059 | 0.049 ± 0.062 | 0.069 ± 0.094 | 0.560 |
FEV1 forced expiratory volume 1-s, VC vital capacity, TLC total lung capacity, FRC functional residual capacity, RV residual volume, Raw total airway resistance, sRaw specific airway resistance, LCI lung clearance index, Sacin acinar slope, Scond conductive slope