Table 3. Associations of maternal hair cortisol concentration (HCC) with amygdala microstructural parameters assessed separately in boys and girls.
Boys | Girls | ||||||||
---|---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | ||||||
Side tested | Image metric | R2 | R2 | HCC β | HCC p-value | R2 | R2 | HCC β | HCC p-value |
Left | FA | 0.433 | 0.537 | −0.339 | 0.023 | 0.157 | 0.239 | 0.340 | 0.372 |
MD | 0.489 | 0.497 | 0.090 | 0.462 | 0.445 | 0.449 | −0.072 | 0.667 | |
ODI | 0.124 | 0.215 | 0.317 | 0.085 | 0.132 | 0.159 | −0.194 | 0.648 | |
NDI | 0.622 | 0.654 | −0.189 | 0.089 | 0.522 | 0.530 | 0.109 | 0.648 | |
Right | FA | 0.368 | 0.443 | −0.287 | 0.047 | 0.301 | 0.306 | 0.091 | 0.736 |
MD | 0.508 | 0.571 | 0.264 | 0.047 | 0.497 | 0.506 | 0.111 | 0.736 | |
ODI | 0.149 | 0.236 | 0.309 | 0.047 | 0.362 | 0.378 | −0.149 | 0.736 | |
NDI | 0.581 | 0.623 | −0.215 | 0.047 | 0.571 | 0.573 | 0.050 | 0.736 |
Model 1: Gestational age at MRI, gestational age at birth, birth weight z-score, Scottish Index of Multiple Deprivation 2016 quintile. Model 2: Model 1 + (maternal HCC). p-values are FDR adjusted. FA, fractional anisotropy; MD, mean diffusivity; ODI, orientation dispersion index; NDI, neurite density index; HCC, hair cortisol concentration; R2, coefficient of determination; β, standardised beta coefficient; p-value, FDR adjusted probability value.