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. 2020 Nov 16;130(12):6718–6727. doi: 10.1172/JCI136057

Figure 2. Foxp3+ cells are critical for long-term survival after heart transplantation.

Figure 2

(A) Intravital 2-photon (2P) imaging depicting Foxp3+ cells infiltrating BALB/c hearts 6 days after transplantation into B6 Foxp3 IRES-GFP mice (Foxp3+ cells: green; quantum dot–labeled [q-dot–labeled] vessels: red; second harmonic generation [SHG]: blue) (n = 3). (B) Kaplan-Meier survival curves of BALB/c hearts after transplantation into (▲) B6 recipients (n = 5) or (▼) DT-treated B6 Foxp3-DTR mice (n = 5). Histological appearance (H&E) of (C) long-term-surviving BALB/c heart after transplantation into B6 recipient and (D) rejected heart after transplantation into DT-treated B6 Foxp3-DTR host. All recipients were treated with perioperative costimulatory blockade (CSB). Scale bars: 30 μm (A) and 100 μm (C and D).