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. 2020 Nov 16;130(12):6718–6727. doi: 10.1172/JCI136057

Figure 4. Lymphatic drainage from lung allograft is reestablished within 21 days after transplantation.

Figure 4

(A) Immunostaining of VEGFR-3 and Foxp3 in bronchus-associated lymphoid tissue in BALB/c lung 30 days after transplantation into B6 recipient that was treated with costimulatory blockade. Representative images and quantification of intensity of fluorescent dye (dextran–Alexa Fluor 488) in (B) draining mediastinal lymph nodes (LN) (original magnification, ×100) and (C) left lungs (original magnification, ×50) in naive B6 mice, B6 mice 7 days or 21 days after transplantation (Txp) of BALB/c lungs (DAPI blue) (n = 5). Lung recipients were treated with perioperative costimulatory blockade. Scale bars: 100 μm (A and B) and 200 μm (C). Data are expressed as mean ± SEM. One-way ANOVA was used to compare the means. NS, not significant.