(A) Colonic slow waves from 1-, 2-, and 3-week-old Ednrb+/+ and Ednrb–/– mice, and 3-week-old Ednrb+/+ and Ednrb–/– mice treated with Clod. s/div, seconds/division. (B and C) The amplitudes (B) and frequencies (C) of colonic slow waves of 1-, 2-, and 3-week-old Ednrb+/+ and Ednrb–/– mice are shown. Data shown represent results from 3 independent experiments. One-way ANOVA: *P < 0.05; **P < 0.01; ***P < 0.001.