Table 1. List of recent clinical trials involved in investigating approaches in managing radiation-induced neuropathies.
| Trial title | Identifier | Sponsor | Type of study | Primary treatment | Endpoint status |
|---|---|---|---|---|---|
| Gustatory Function Following Radiotherapy in Head and Neck Cancer [1] | NCT03738657 | Royal Marsden NHS Foundation Trust | Cross-sectional | N/A | Recruiting |
| Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations [2] | NCT03824925 | Dow University of Health Sciences | Double-blind randomised controlled trial – Phase III |
*Placebo *Zinc sulfate 220mg |
Completed |
| Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With Paranasal Sinus or Nasopharyngeal Cancer [3] | NCT03049358 | Stanford University | Single blinded randomised trial – Phase I | *Olfactory training | Terminated |
| Effect and Safety of Apatinib on Radiation-Induced Brain Injury [4] | NCT04152681 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Single group assessment – Phase II | *Apatinib 250 mg | Recruiting |
| Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy [5] | NCT04151082 | M.D. Anderson Cancer Center | Single group assessment – Phase I/II |
*Methylprednisolone *Prednisone |
Recruiting |
| Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients. (stREnGTH) [6] | NCT03747562 | University Hospital, Ghent | Multi-center double- blinded randomised controlled trial – Phase III |
*Placebo *Gabapentin 100 mg |
Not yet recruiting |
| Efficacy of Acupuncture in Radiotherapy-induced Dysphagia in Patients With Head and Neck Cancer [187] | NCT03336775 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Universit | Single blinded randomized trial | *Acupuncture *Methylprednisolone 80 mg |
Recruiting |
| PRO-ACTIVE: Prophylactic Swallow Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer [188] | NCT03455608 | University Health Network, Toronto | Randomized | *Swallowing Training | Recruiting |
| Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia [205] | NCT02198131 | Wake Forest University Health Sciences | Single group assessment | *Pulse Dye Laser Surgery | Completed |