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. 2020 Nov 20;218(2):e20200675. doi: 10.1084/jem.20200675

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© 2020 Richard et al.

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Figure 1. — Homology model of murine TLR4 D298G/N397I. (A) Superimposed models of murine WT vs. TLR4 D298G N397I. The x-ray crystal structure of murine TLR4 (green) with MD-2 (blue) is superimposed onto a model of the double mutant (pink). Inset panels show details around the two SNP sites, D298G (left) and N397I (right). (B) Alignment and DNA sequences of WT and homozygous mutant mice expressing both the D298G and N397I TLR4 SNPs (TLR4-SNP mice).