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. 2020 Nov 20;218(2):e20200675. doi: 10.1084/jem.20200675

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© 2020 Richard et al.

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Figure 7. — Altered susceptibility of TLR4-SNP mice to RSV infection. (A) WT and TLR4-SNP mice were infected with RSV A/Long (∼5 × 10⁶ PFU i.n.). The lungs were harvested for M1 and M2 gene expression analysis by qRT-PCR on day 6 after infection. Each point represents the responses of individual mice from two separate experiments. Columns represent the mean ± SEM. Data were analyzed by two-way ANOVA with Tukey’s post hoc test. RSV-infected WT vs. TLR4-SNP: Tnf, P = 0.0003; Il1b, P = 0.0006; Ptgs2, P < 0.0001; Chil3, P < 0.0001; Mrc1, P = 0.0005; Arg1, P = 0.0047; Pparg, P = 0.0003. (B) WT and TLR4-SNP mice were infected with RSV A/Long as in A. The lungs were harvested for histopathology analysis on day 6 after infection. Each column represents the mean ± SEM of the combined results of two separate experiments. Data were analyzed by two-way ANOVA with Tukey’s post hoc test. RSV-infected WT vs. TLR4-SNP: peribronchiolitis, P = 0.0051; perivasculitis, P = 0.0039; interstitial pneumonitis, P = 0.0002; alveolitis, P = 0.0039.