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The interplay between HIF-1 and ROS under hypoxic condition. PHD: prolyl hydroxylase; LON: mitochondrial ATP dependent matrix protease; COX-4: cytochrome c oxidase IV-2; PDK-1: pyruvate dehydrogenase (PDH) kinase 1; LDHA: lactate dehydrogenase A; BNIP3: BCL2 and adenovirus E1B 19 kDa-interacting protein 3; ISCU1/2: iron–sulfur cluster assembly protein.
