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. 2020 Nov 17;2020:9457101. doi: 10.1155/2020/9457101

Figure 1.

Figure 1

(a) The target for SE, obtained from Rhubarb, Salvia miltiorrhiza, Safflower, and Astragalus radix. (b) The network of targets and components of SE. Violet, yellow, green, and red points, respectively, represent Rhubarb, Astragalus radix, Salvia miltiorrhiza, and Safflower active components. The orange points represent targets. The lines represent interaction. (c) The flow of searching core targets shared by CRSAS and AKI. First, 1,444 targets were searched. Second, with reference to the double median value of 58 degrees, 386 core targets were selected. Then, 206 core targets were obtained with reference to the median 4745.07 and 0.543467 of the network parameters, betweenness, and closeness to the center, respectively. (d) Enrichment analysis of GO biological process of SE active ingredient potential therapeutic target for AKI using biological process (BP), cellular component (CC), and molecular function (MF) terms. The red, blue, and purple represent BP, CC, and MF, respectively. (e) Pathway enrichment analysis of the core targets of SE (Rhubarb, Astragalus radix, Salvia miltiorrhiza, and Safflower), as shown in the bubble chart. The green-red gradient color map represents low to high enrichment and the black circle represents the count.