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. 2020 Nov 17;2020:8845635. doi: 10.1155/2020/8845635

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Copyright © 2020 Rahele A. Farahani et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

miRNAs dysregulated in MetS-EVs are capable of targeting mitochondria-related genes. Predicted mitochondria target genes of differentially expressed miRNAs were identified (MitoCarta2.0) and classified by their cellular component (a), molecular function (b), and biological process (c). miRNAs dysregulated in MetS-EVs are capable of targeting several genes implicated in mitochondrial energy pathways, including the electron transport chain complexes I, II, III, IV, and V and the tricarboxylic acid (TCA) cycle.