Figure 8.
MetS-EVs failed to improve poststenotic kidney injury. (a) Representative kidney dihydroethidium (DHE, red), periodic acid-Schiff (PAS), and trichrome staining in study groups. (b) Renal production of superoxide anion, tubular injury score, and tubulointerstitial fibrosis that increased in MetS+RAS compared to Lean and MetS, decreased in MetS+RAS+Lean-EVs, but not in MetS+RAS+MetS-EVs. ∗p < 0.05 vs. Lean; †p < 0.05 vs. MetS; ‡p < 0.05 vs. MetS+RAS; #p < 0.05 vs. MetS+RAS+Lean-EVs.