Table 1.
Systemic characteristics and single-kidney function in study groups at 16 weeks.
| Lean | MetS | MetS+RAS | MetS+RAS+ LeanEVs | MetS+RAS+ MetS-EVs | |
|---|---|---|---|---|---|
| Body weight (kg) | 72.4 ± 7.2 | 92.0 ± 6.7∗ | 92.4 ± 5.7∗ | 90.4 ± 8.6∗ | 88.4 ± 7.1∗ |
| MAP (mmHg) | 93.6 ± 4.9 | 124.2 ± 7.2∗ | 125.1 ± 6.6∗ | 120.6 ± 13.0∗ | 120.6 ± 8.4∗ |
| Degree of stenosis (%) | 0 | 0 | 60.0 ± 13.9∗† | 65.0 ± 7.6∗† | 67.5 ± 6.0∗† |
| Total cholesterol (mg/dl) | 84.5 (78.0-90.1) | 328.0 (315.1-481.1)∗ | 345.2 (321.2-406.2)∗ | 345.2 (323.7-413.1)∗ | 316.5 (310.5-329.5)∗ |
| LDL cholesterol (mg/dl) | 32.7 ± 5.6 | 338.5 ± 96.8∗ | 363.8 ± 49.0∗ | 339.8 ± 35.6∗ | 352.4 ± 39.3∗ |
| Triglycerides (mg/dl) | 7.6 (5.9-8.7) | 17.3 (13.0-22.5)∗ | 15.1 (14.2-16.1)∗ | 16.7 (12.9-17.3)∗ | 14.8 (12.4-17.0)∗ |
| Fasting glucose (mg/dl) | 121.7 ± 5.4 | 113.5 ± 15.3 | 115.5 ± 14.1 | 117.8 ± 18.4 | 121.8 ± 17.2 |
| Fasting insulin (μU/ml) | 0.4 (0.4-0.5) | 0.8 (0.7-0.8)∗ | 0.8 (0.7-0.8)∗ | 0.8 (0.7-0.8)∗ | 0.7 (0.7-0.8)∗ |
| HOMA-IR score | 0.6 (0.5-0.7) | 1.9 (1.5-1.9)∗ | 1.8 (1.7-1.8)∗ | 1.7 (1.7-1.8)∗ | 1.8 (1.5-1.9)∗ |
| Renal volume (ml) | 131.9 ± 13.7 | 217.3 ± 11.8∗ | 185.0 ± 19.0∗† | 229.5 ± 47.3∗‡ | 168.5 ± 25.1∗†# |
| RBF (ml/min) | 502.0 ± 69.3 | 811.6 ± 78.9∗ | 615.4 ± 74.4∗† | 840.3 ± 241.6∗‡ | 660.3 ± 67.6∗†# |
| GFR (ml/min) | 74.8 ± 9.7 | 138.9 ± 21.2∗ | 97.2 ± 11.9∗† | 128.0 ± 33.3∗‡ | 93.8 ± 13.8∗†# |
MAP: mean arterial pressure; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; RBF: renal blood flow; GFR: glomerular filtration rate. ∗p < 0.05 vs. Lean; †p < 0.05 vs. MetS; ‡p < 0.05 vs. MetS + RAS; #p < 0.05 vs. MetS+RAS+Lean-EVs.