FIG 4.

Correlation of serology assays versus neutralization activities for convalescent plasma donors. (A) Linear regression of HIV-S NT₅₀ values (abscissa) versus serological assay values (ordinate). Number of samples is indicated in each graph; r² = goodness of fit; AU, arbitrary units; NP, nucleocapsid protein. (B) Spearman correlation coefficients, r, of neutralization and serological assays. n = 137 samples; NP, nucleocapsid protein. (C) Distributions of CP donor sample HTSA scores within indicated HIV-S NT₅₀ groups using Ortho total Ig (left), Ortho IgG (center), or Abbott IgG (right) assay. (D) Frequencies of convalescent donor S1 protein and nucleocapsid protein (NP) ELISA values defined in Fig. S4B in the supplemental material. n = 241 samples; DP, double positive. (E) Distribution of NT₅₀ values corresponding to populations defined in Fig. S4B in the supplemental material. n = 4 to 51; Kruskall-Wallis test; *, P < 0.05; **, P < 0.01.