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(a,b): 3D and 2D interaction diagram of cucurbitacin G 2-glucoside with high afinity for JAK2. (a, b: 4GFM_G); signalling forming hydrogen bonds with residues Ser 936, Arg980, Asp939, Leu855, Glu1015 and Asp976 and a hydrogen bond energy of (−9.43 kcal/mol).
