Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 1;33(12):2397–2406. doi: 10.1038/s41379-020-0581-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Schematic of functional domains of MAP2K1 (transcript NM_002755), to include number of cases with each in-frame deletion (black bars; length~number of cases) and sites of pathogenic missense mutations (black arrows). The majority of in-frame deletions are present in the catalytic core. b Summary of clinical features and molecular alterations in MAP2K1 in-frame deletion melanomas. NES nuclear export signal, NRR negative regulatory region, ATP ATP binding site, Pro rich proline-rich domain, TERTp TERT promoter.