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. 2020 Jun 22;33(12):2483–2498. doi: 10.1038/s41379-020-0591-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Shown is a representative specimen (case 11). E-cadherin-negative tubular elements spread around a mammary duct. a The upper panel shows details from the HE-stained section (×100 magnification, scale bar corresponds to 300 µm). Photomicrographs of immunohistochemical stainings for E-cadherin and beta-catenin from consecutive serial sections are also provided (×100 magnification, lower panels). Please note that cancerous tubular elements lack E-cadherin immunoreactivity, while the normal mammary duct in the center stains positive for E-cadherin. Note that beta-catenin immunoreactivity in cancerous tubular elements was weaker than in the normal mammary duct. b Immunohistochemical staining for P-cadherin from a consecutive serial section. Please note the same normal mammary duct in the center. The normal mammary duct shows regular immunoreactivity for P-cadherin confined to the myoepithelial cell layer. Cancerous tubular elements spread around this duct are positive for P-cadherin (inset).