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. 2020 Jun 22;33(12):2483–2498. doi: 10.1038/s41379-020-0591-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Shown is the protein-coding sequence of the CDH1/E-cadherin gene. Lesion histology is coded by the symbol shape, as indicated in the legend. Mutation type is coded by the symbol color, as indicated in the legend. For details see Supplementary data Table 2. b Genome-wide view of CNAs detected in ILBCs with tubular elements (n = 11) based on whole-genome DNA CN profiles. Chromosomal localization is plotted on the x axis. The overall frequency of CN gains (red) and CN loss (blue) is plotted on the y axis.