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. 2020 Jun 22;33(12):2483–2498. doi: 10.1038/s41379-020-0591-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The percentage of Ki67-positive tumor cells was quantified in ILBC cells arranged in conventional growth pattern (a) or tubular elements (b). Shown are three representative fields of view (FOVs) of case 3. Ki67-stainings are shown in the left panels (×200 magnification) and Ki67 quantification by CognitionMaster software is shown in the right panels. c Traditional Tukey plot showing the distribution of Ki67 indices [% per FOV] in n = 11 ILBCs analyzed. Horizontal lines indicate the median Ki67 across multiple FOVs. Boxes indicate the interquartile ranges and whiskers indicate the 1.5-fold interquartile distance, or the minimal/maximal values, whichever is shorter. Statistical significance was determined with the Mann–Whitney test.