Table 1.
Clinicopathological characteristics.
| Case | Age | Tissue | Histology, grade | Growth pattern | LCIS | pTNM | ER | PR | HER2 | HER2 FISH | Ki67 (%) | E-cad. | beta- ctn. | CDH1 status | LOH 16q22.1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 69 | RS | ILBC-TE, G3 | sol, trab, te (60%) | LCIS | pT2m, pN0 | pos | neg | 2+ | neg | 20 | neg | fpos | p.H97Ifs*20 | LOH |
| 2 | 79 | RS | ILBC-TE, G2 | sol, clas, te (20%) | LCIS | pT1c, pNx | pos | pos | 1+ | na | 20 | neg | fpos | p.F86Sfs*12 | LOH |
| 3 | 64 | RS | ILBC-TE, G2 | sol, clas, te (60%) | rpM1 (ovary) | pos | pos | 1+ | na | 20 | neg | fpos | p.S9* | cnLOH | |
| 4 | 50 | NB | ILBC-TE, G2 | trab, disp, te (20%) | LCIS | pTxmBi, pNx | pos | pos | 2+ | neg | 15 | faint | fpos | p.E841*, p.Y523* | na |
| 5 | 61 | RS | ILBC-TE, G2 | sol, trab, te (15%) | LCIS | pT1cm, pN0 | pos | pos | 1+ | na | 15 | neg | fpos | p.Q23* | cnLOH |
| 6 | 56 | NB | ILBC-TE, G2 | clas, te (20%) | pT1b, pN0 | pos | neg | 1+ | na | 20 | neg | neg | wt | LOH | |
| 7 | 58 | NB | ILBC-TE, G2 | clas, disp, te (15%) | LCIS | pT2, pN0 | pos | pos | 1+ | na | 20 | neg | fpos | p.Q177* | LOH |
| 8 | 50 | NB | ILBC-TE, G2 | trab, te (5%) | pT2, pN1mi | pos | pos | 1+ | na | 20 | neg | neg | p.E445* | LOH | |
| 9 | 42 | RS | ILBC-TE, G2 | clas, te (60%) | LCIS | pT2m, pN1 | pos | pos | 1+ | na | 15 | neg | fpos | Splicing | LOH |
| 10 | 60 | RS | ILBC-TE, G2 | clas, te (40%) | pT2, pN0 | pos | pos | 2+ | neg | 20 | neg | fpos | p.T295I | na | |
| 11 | 59 | RS | ILBC-TE, G2 | clas, te (20%) | pT1c, pN1mi | pos | pos | 1+ | na | 15 | neg | fpos | p.P537Rfs*20 | LOH | |
| 12 | 75 | NB | ILBC-TE, G2 | clas, te (25%) | pT3, pN1 | pos | pos | 1+ | na | 20 | neg | fpos | p.Q23* | LOH | |
| 13 | 48 | RS | ILBC-TE, G3 | clas, trab, te (15%) | LCIS | pT1c, pN1 | pos | pos | 1+ | na | 25 | neg | fpos | wt | LOH |
Beta-ctn beta-catenin, Bi bilateral, clas classical growth pattern, cn copy number-neutral, E-cad. E-cadherin, fpos focally positive, ILBC-TE invasive lobular breast cancer with tubular elements, LCIS lobular carcinoma in situ, LOH loss of heterozygosity, NB needle biopsy, neg negative, pos positive, RS resection specimen, sol solid growth pattern, trab trabecular growth pattern, te (%) tubular elements (% tumor area), wt wild-type.