Table 1.
Baseline characteristics
| Variables | Intention to treat analysis (n 90) | Per protocol analysis (n 58) | ||||
|---|---|---|---|---|---|---|
| Antibiotic (%) 42 (47) |
Placebo (%) 48 (53) |
p value | Antibiotic (%) 29 (50) |
Placebo (%) 29 (50) |
p value | |
| Men (%) | 18 (43) | 23 (48) | 0.675 | 13 (45) | 11 (38) | 0.395 |
| Age, years ( median, interquartile range) | 48.5 (24) | 49 (25) | 0.768 | 55 (20) | 45 (20) | 0.194 |
| Body mass index ( median, interquartile range) | 27 (7) | 28 (6) | 0.874 | 28 (9) | 27 (5) | 0.428 |
| Previous gallstone symptom (%) | 13 (31) | 11 (30) | 0.476 | 10 (34) | 6 (21) | 0.379 |
| No comorbidity (%) | 13 (31) | 21 (44) | 0.277 | 8 (28) | 14 (48) | 0.175 |
| Symptom duration (median, interquartile range) | 4 (3) | 4 (2) | 0.653 | 4 (3) | 4 (1) | 0.178 |
| Method of approach (%) | 0.487 | 0.838 | ||||
| Laparoscopic | 37 (88) | 38 (79) | 26 (90) | 25 (86) | ||
| Open | 1 (2) | 3 (6) | 1 (3) | 2 (7) | ||
| Converted | 4 (10) | 7 (15) | 2 (7) | 2 (7) | ||
| Body temperature inclusion day (median, interquartile range) | 37 (21) | 37 (1) | 0.810 | 37 (2) | 37 (2) | 0.433 |
| C-reactive protein inclusion day (median, interquartile range) | 57 (121) | 81 (129) | 0.140 | 46 (129) | 76 (79) | 0.409 |
| White blood cell count inclusion day, × 109/l (median, interquartile range) | 10 (5) | 12 (7) | 0.105 | 9 (6) | 10.5 (8) | 0.600 |
| Temp day 2 (median, interquartile range) | 37 (2) | 37(0.5) | 0.398 | 37 (2) | 37 (1) | 0.893 |
| C-reactive protein day 2 (median, interquartile range) | 760 (175) | 80 (118) | 0.650 | 56 (151) | 70 (52) | 0.844 |
| White blood cell count inclusion day, × 109/l day 2 (median, interquartile Range) | 10 (7) | 11 (5) | 0.536 | 8 (8) | 10 (4) | 0.545 |
| Antibiotic treatment start postop (%) | 5 (12) | 10 (21) | 0.396 | -- | -- | |
| Postop complication (%) | 8 (19) | 14 (29) | 0.193 | 3 (10) | 3(10) | 0.665 |