TABLE 4.

Summary of the bone healing simulations and their characteristics.

Simulation name	Scaffold configuration	Figure	Latency period	Graft stimulatory effects	Surface guidance features
Baseline model	Soft	5D 4B (2)*	No	None	None
Non-stimulated bone regeneration model	Soft	5E	Yes	None	None
Graft stimulatory effect on cell migration	Soft	6A 4B (3)*	Yes	Osteoconductive	None
Graft stimulatory effect on cell proliferation	Soft	6B 4B (4)*	Yes	Osteoconductive	None
Graft stimulatory effect on cell differentiation	Soft	6C	Yes	Osteoinductive	None
Combined graft osteoconductive and osteoinductive effects	Soft	6D 4B (5)*	Yes	Osteoconductive + osteoinductive	None
Bone graft-contained progenitor cells	Soft	6E 4B (6)*	Yes	Initial seeding of progenitor cells	None
Combined bone graft-contained progenitor cells with osteoconductive and osteoinductive effects	Soft	6F 4B (7)*	Yes	Osteoconductive + osteoinductive + initial seeding of progenitor cells	None
Surface-guided migration with non-stimulated bone regeneration	Soft	7A	Yes	None	Surface-guided migration
Surface ECM deposition with non-stimulated bone regeneration	Soft	7B	Yes	None	Surface ECM deposition
Surface-guided migration with bone graft osteoconductive effects	Soft	7C	Yes	Osteoconductive	Surface-guided migration
Surface ECM deposition with bone graft osteoconductive effects	Soft	7D 4B (8)*	Yes	Osteoconductive	Surface ECM deposition
Surface ECM deposition with bone graft osteoconductive effects	Stiff	8B	Yes	Osteoconductive	Surface ECM deposition

*The number in parentheses refers to the bar chart reference number for the simulation case on Figure 4B.