Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Physiol. 2020 Jul 24;598(21):4969–4994. doi: 10.1113/JP280243

Figure 12. Disinhibition of BötC abolishes active expiration and restores eupneic-like respiratory pattern in SH rats.

Figure 12.

Panel A: raw and integrated (∫) recordings of cervical vagus (cVN), abdominal (AbN) and phrenic (PN) nerve activities of a SH in situ preparation, representative from the group, illustrating the effects of bilateral microinjections of strychnine (10 μM) in the BötC (arrows). Note the marked reduction of AbN late-E bursts after the disinhibition of BötC with strychnine. Panel B: expanded recordings from panel A, showing, in details, the respiratory motor pattern of SH rats before and after microinjections of strychnine in the BötC. Panels C-H: average values of PN burst frequency and amplitude, cVN post-I activity and duration, and AbN activity during E1 and E2 phases, before and after microinjections of strychnine in the BötC of SH in situ preparations (n=8). * different from baseline, P<0.05 (paired t test). Panel I: coronal section of brainstem from a SH in situ preparation, illustrating the sites of bilateral microinjections in the BötC. The injection sites in each animal of the group are represented as the grey area in the schematic drawing on the right.