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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Physiol. 2020 Jul 24;598(21):4969–4994. doi: 10.1113/JP280243

Figure 8. Respiratory motor pattern and BötC neuronal activity in rats exposed to sustained hypoxia.

Figure 8.

Panel A: raw and integrated (∫) recordings of cervical vagus (cVN), abdominal (AbN) and phrenic (PN) nerve activities of control and SH in situ preparations, representative from their groups, under normocapnia. Note that SH preparations exhibit AbN late-E bursts (active expiration) at resting conditions. Panels B-C: recordings of post-I and aug-E neurons (unit and instantaneous frequency), respectively, a two in situ preparations of SH rats, representative from the group, illustrating the relationship between BötC neuronal activity and active expiration. In panel B, note the absence of action potentials in post-I activity when late-E burst emerged. In panel C, note the increased firing frequency of aug-E neurons in the presence of AbN late-E burst, in comparison to a respiratory cycle when AbN late-E burst skipped (skipping). Panels D-H: Average values of PN frequency, times of inspiration and expiration, and cVN post-I and AbN E2 activities of in situ preparations of control (n=9) and SH rats (n=9). * different from control group, P<0.05 (unpaired t test).